Endocrine Abstracts

Introduction: The present study aimed to investigate whether women who developed gestational diabetes mellitus (GDM) comply with the guidelines for gestational weight gain (GWG) according to their pre-pregnancy Body Mass Index (BMI).Methods: A retrospective study was conducted involving 195 pregnant women with GDM, aged 25–45 years, attending an academic hospital outpatient clinic. These women were divided into three groups according to pre-pregnanc...

Introduction: Gestational Diabetes Mellitus (GDM) is a disorder of glucose tolerance which is diagnosed for the first time during pregnancy. Thyroid disease is common in women of reproductive age and during gestation; both diseases have an adverse impact on pregnancy outcomes. The aim of this study was to assess the clinical and ultrasonographic characteristics in women with co-existing GDM and thyroid disease.Material and methods: In total, 112 pregnant...

Introduction: Data on the effect of hormone replacement therapy (HRT) and tibolone on lipoprotein(a) (Lp(a)), an independent risk factor for cardiovascular disease, are heterogeneous and conflicting. The aim of this study was to investigate the effect of HRT and tibolone on Lp(a) concentrations in post-menopausal women.Methods/design: MEDLINE, Scopus, EMBASE and Cochrane databases were searched (up to February 2016). Two researchers identified randomized...

Introduction: Adipokines and ghrelin exert well-documented effects on energy expenditure and glucose metabolism. Experimental data also support a role in bone metabolism, although data from clinical studies are conflicting. The purpose of this cross-sectional study was to investigate the association of serum concentrations of leptin, adiponectin and ghrelin with bone mineral density (BMD) in post-menopausal women.Methods/design: BMD in lumbar spine and f...

Introduction: Assessing the quality of life of patients with thyroid disease does represent a challenge. ThypRO questionnaire has been developed recently and comprises a reliable and valid scale structure of a patient-reported outcome measuring thyroid-specific quality of life.Material and methods: The standard methodology for translation of patient-reported outcomes was followed. Two independent translators, Greek native speakers, fluent in english, wer...

Introduction: The aim of this study was to systematically review the literature for studies that have investigated possible differences in prevalence of subclinical Cushing’s syndrome (SCS) and related clinical implications between patients with unilateral (UAI) and bilateral adrenal incidentalomas (BAI) and to meta-analyze the best evidence available.Methods: Electronic databases PubMed, MEDLINE and EMBASE were systematically searched. Main study o...

Introduction: The role of thyroxine (T4) during embryo development is recognised as crucial. The research question of this study was if embryo quality and reproductive outcomes after IVF are affected by maternal thyroid function and/or thyroid auto-immunity (TAI).Methods/design: We conducted a prospective study (ThyrART), assessing embryo quality and reproductive outcome of women undergoing ovarian stimulation with a flexible GnRH-antagonist p...

Introduction: The evidence of the impact of OS for IVF and thyroid function or autoimmunity is inconclusive, based mainly on assessments just before and after OS. The aim of this study was to closely monitor the changes on thyroid function and autoimmunity throughout OS for IVF.Description of methods/designs: In a prospective, interventional study, a flexible GnRH-antagonist protocol was applied to 42 women undergoing IVF ((classic or ICSI), with initiat...

Objective: Whereas parathyroidectomy (PTx) has an established benefit in patients with symptomatic primary hyperparathyroidism (PHPT), its efficacy in patients with mild (asymptomatic) PHPT has not been proven. The aim of this study was to systematically investigate and meta-analyze the best available evidence from randomized-controlled trials regarding the efficacy of PTx on fracture risk (primary endpoint), as well as bone mineral density (BMD), serum calcium concentrations,...

Objective: Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). The purpose of this study was to systematically investigate and meta–analyze the best available evidence from randomized–controlled trials (RCTs) regarding the efficacy and safety of statins in children and adolescents with FH.Methods: A comprehensive search was conducted in PubMed, Scopus and Cochrane, up to July 10, 2019. Data were expres...